Opus Dei began its apostolic activities in the United States in Chicago in 1949, when Sal Ferigle, a young physics graduate student, and Fr. Joseph Muzquiz, one of the first 3 priests to be ordained for Opus Dei, arrived in Chicago. The first center was established near the University of Chicago.
Today there are more than 3,000 members in the United States, and a great many more people who participate in Opus Dei's activities of spiritual formation. These activities are organized from 60 centers in 19 cities: Boston; Chicago; Dallas; Delray Beach, Florida; Houston; Los Angeles; Miami; Milwaukee; New York; Pittsburgh; Princeton, New Jersey; Providence; St. Louis; San Antonio; San Francisco; South Bend, Indiana; South Orange, New Jersey; Urbana, Illinois; Reston, Virginia; and Washington, D.C. Opus Dei also organizes activities in many other cities.
A number of Opus Dei members are involved in programs to assist the underprivileged. Supplementary educational programs at Midtown and Metro Centers, for example, have helped thousands of African-American and Hispanic youth in inner-city Chicago.
Similar programs exist in the South Bronx section of New York and in Washington, D.C.
Additionally, Opus Dei members, in cooperation with others, operate six secondary schools in the United States: The Heights and Oakcrest near Washington, D.C.; Northridge Prep and The Willows near Chicago; the Montrose School near Boston; and Western Academy near Houston. IESE Business School, the graduate business school of the University of Navarra, has a campus in Manhattan.
Opus Dei also provides spiritual guidance to several residences for university students, the largest of which is Bayridge Residence for women, in Boston. Other residences for university women are Petawa Residence in Milwaukee and Westfield Residence in Los Angeles. Windmoor Study Center is a residence for college men in South Bend, Indiana.
In 1991, Cardinal Joseph Bernardin, Archbishop of Chicago, entrusted the parish of St. Mary of the Angels to priests of Opus Dei. In 2016, Cardinal Timothy Dolan, Archbishop of New York, did likewise with the parish of St. Agnes, in Manhattan. The Catholic Information Center in Washington, D.C., and the Holy Cross Chapel in Houston, Texas, have also been entrusted to priests of Opus Dei.
Opus Dei's U.S. headquarters are located in New York City. Currently serving as Vicar for the United States is Msgr. Thomas Bohlin.