During this time of preparation for the centenary, which we have begun with regional assemblies, the Prelate invites us to reflect on Opus Dei’s identity, history, and mission. The purpose of this series is to delve deeper into the charism by focusing on one of its essential aspects: the sanctification of work. This first article explores the specific role of the Work within the Church and develops the concepts of vocation and mission in the context of ordinary life.